ANEMIA MEGALOBLASTICA PDF

Pathophysiology[ edit ] There is a defect in DNA synthesis in the rapidly dividing cells and to a lesser extent, RNA and protein synthesis are also impaired. Therefore, unbalanced cell proliferation and impaired cell division occur as a result of arrested nuclear maturation so the cells show nuclear-cytoplasmic asynchrony. In the bone marrow , most megaloblasts are destroyed prior to entering the peripheral blood intramedullary hemolysis some can escape the bone marrow macrocytes to peripheral blood but they are destroyed by the reticulo-endothelial system extramedullary hemolysis. The gold standard for the diagnosis of Vitamin B 12 deficiency is a low blood level of Vitamin B A low level of blood Vitamin B 12 is a finding that normally can and should be treated by injections, supplementation, or dietary or lifestyle advice, but it is not a diagnosis. Hypovitaminosis B 12 can result from a number of mechanisms, including those listed above.

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What Is Megaloblastic Anemia? Megaloblastic anemia is a type of anemia , a blood disorder in which the number of red blood cells is lower than normal. Red blood cells transport oxygen through the body.

There are many types of anemia with different causes and characteristics. Megaloblastic anemia is characterized by red blood cells that are larger than normal. Because the cells are too large, they may not be able to exit the bone marrow to enter the bloodstream and deliver oxygen.

Causes of Megaloblastic Anemia The two most common causes of megaloblastic anemia are deficiencies of vitamin B or folate. These two nutrients are necessary for producing healthy red blood cells. Vitamin B Deficiency Vitamin B is a nutrient found in some foods like meat, fish, eggs, and milk.

Megaloblastic anemia caused by vitamin B deficiency is referred to as pernicious anemia. Folate is found in foods like beef liver, spinach, and Brussels sprouts. Folate is often mixed up with folic acid — technically, folic acid is the artificial form of folate, found in supplements.

You can also find folic acid in fortified cereals and foods. Your diet is an important factor in making sure you have enough folate. Pregnant women are more likely to have folate deficiency, because of the high amounts of folate needed by the developing fetus.

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