You can help by adding to it. December Direct removal of lactate from the body e. Painted turtles hibernate buried in mud or underwater and do not resurface for the entire winter. As a result, they rely on anaerobic respiration to provide the majority of their energy needs. In the anoxic conditions where anaerobic respiration is dominant, calcium levels in the blood plasma increase. In domesticated ruminants, lactic acidosis may occur as a consequence of ingesting large amounts of grain, especially when the rumen population is poorly adapted to deal with grain.
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Lactic acidosis has a wide range of underlying causes, including carbon monoxide poisoning , cholera , malaria , and asphyxiation. Some common causes include: Heart disease Conditions such as cardiac arres t and congestive heart failure may reduce the flow of blood and oxygen throughout the body.
This can increase lactic acid levels. Severe infection sepsis Any type of severe viral or bacterial infection can cause sepsis. People with sepsis may experience a spike in lactic acid, caused by reduced oxygen flow.
HIV HIV medications, such as nucleoside reverse transcriptase inhibitors , can spike lactic acid levels. They also may cause liver damage. This makes it harder for the body to process lactate. Cancer Cancer cells create lactic acid. This buildup of lactic acid may accelerate as a person loses weight and the disease progresses. Short bowel syndrome short gut While , people with short gut may experience a buildup of D-lactic acid, caused by bacterial overgrowth in the small bowel.
Acetaminophen use Regular, frequent use of acetaminophen Tylenol can cause lactic acidosis, even when taken in the correct dosage. This is because it can cause an accumulation of pyroglutamic acid in the blood. Chronic alcoholism Drinking alcohol to excess over an extended period of time can lead to lactic acidosis and alcoholic ketoacidosis.
Alcoholic ketoacidosis is a potentially fatal condition if left untreated, but it can be combated with intravenous IV hydration and glucose. Alcohol increases phosphate levels, which negatively impact the kidneys. It can also cause nausea and weakness.
Lactic acidosis and diabetes A specific class of oral diabetes medication , called biguanides, can cause a buildup of lactic acid levels.
Metformin Glucophage is one of these drugs. Metformin is also used off-label to treat polycystic ovarian syndrome. In people with diabetes, lactic acidosis may be more of a concern if kidney disease is also present.
If you have diabetes and experience any symptoms of lactic acidosis, call or go to an emergency room immediately. How is it diagnosed? Lactic acidosis is diagnosed through a fasting blood test. Your doctor may instruct you to not eat or drink anything for 8 to 10 hours before taking the test. You may also be instructed to curb your activity level in the hours leading up to the test.
During the test, your doctor may tell you not to clench your fist, as this may artificially spike acid levels. Tying an elastic band around the arm may also have this result.
For these reasons, the lactic acidosis blood test is sometimes done by finding a vein on the back of the hand instead of the arm. What are the treatment options? The best way to treat lactic acidosis is by treating its root cause. For that reason, treatments vary. Lactic acidosis sometimes represents a medical emergency. This requires treating symptoms, regardless of their root cause. Increasing oxygen to the tissues and giving IV fluids are often used to reduce lactic acid levels.
Lactic Acidosis: What You Need to Know